PolyPhen-2 prediction of functional effects of human nsSNPs

PolyPhen-2 report for P08294 A91T (rs17879876)

Query

Protein AccPositionAA1AA2Description
P0829491ATCanonical; RecName: Full=Extracellular superoxide dismutase [Cu-Zn]; Short=EC-SOD; EC=1.15.1.1; Flags: Precursor; Length: 240

Results

Prediction/Confidence  PolyPhen-2 v2.2.2r398

HumDiv

This mutation is predicted to be benign with a score of 0.389 (sensitivity: 0.90; specificity: 0.89)

Confidence

HumVar

Details

Multiple sequence alignment  UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011)
3D Visualization  PDB/DSSP Snapshot 03-Jan-2012 (78304 Structures)