PolyPhen-2 report for P08294 A58T (rs2536512)

Query

Protein Acc	Position	AA₁	AA₂	Description
P08294	58	A	T	Canonical; RecName: Full=Extracellular superoxide dismutase [Cu-Zn]; Short=EC-SOD; EC=1.15.1.1; Flags: Precursor; Length: 240

Results

Prediction/Confidence

PolyPhen-2 v2.2.2r398

HumDiv

This mutation is predicted to be benign with a score of 0.188 (sensitivity: 0.92; specificity: 0.87)

Confidence

HumVar

Details

Multiple sequence alignment

UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011)

QUERY	PNSDSAEWIRDMYAKVTEIWQEVMQR--R----DDDG	A	LHAACQVQPSATL-DAAQPRVTGVVLFRQLAPRAKLDA
sp\|F7H9D9#1	PNSDLAESIRDMHAKITEIWQELTQR--R----DGDG	A	LHAACQVQPSATL-DAAQPRVTGVVLFRQLAPRAKLEA
sp\|F7FQX5#1	--EDLAEQIRDTHAKVSDIWQKLTQR--Q----DDDD	A	LHATCQVQPSATL-DAAQPRVTGVVLFRQLAPRAKLEA
sp\|P41975#1	LGSDTVEQIRDTHAKVTEIWQALTQQ--RAAQGEPAG	A	LHAVCRVQPSATL-DAAQPRVSGLVVFRQLGPGAQLEA
sp\|A3KLR9#1	--SNTEEQIRDMHAKVTEIWQEMMQR--QAAAIDPDA	A	LHAVCRVLPSATL-EAEQPRVSGLVLFRQLRPGALLEA
sp\|Q007T6#1	PGSHMEEQIRDMQAKVTEIWQELTQQ--RAAGGGQEA	A	LHATCSMQPSVLL-DAAQPQVTGLVLFRQLRPGALLEA
sp\|G3TMG2#1	PGSNTAEQIRDMHVKVTEIWQALTHR--GARDGGPGA	D	LYTACSVQPSASI-GAAQPRVTGLVLFRQLAPGAKLEA
sp\|B2CZE9#1	--SNTEEQIRDMHAKVTEIWQEMMQR--QAAAIDPDA	A	LHAVCRVLPSATL-EAEQPRVSGLVLFRQLRPGALLEA
sp\|UPI0000F64D30#1	PSPDLMKQIGDMYAKVTDIWQELTQR--REAASQPNA	A	LHAVCRVQPSATL-DAKQPRVTGLVLFRQSAPEARLEA
sp\|UPI00005A0592#1	-----AAQLSDMHDKVTAIWQQLTQR--AAEPGAPGS	A	LHAACRVQPSASL-DPAQPRVSGLVLFRQPAPGAPLEA
sp\|F1PAS8#1	--------LSDMHDKVTAIWQQLT------------S	A	LHAACRVQPSASL-DPAQPRVSGLVLFRQPAPGAPLEA
sp\|Q33DP1#1	MGPDLAEKINETHAKVLEIWKELRRL--REA---EAT	E	MHAICQVQPSASL-ASDQPRVTGLVLFKQLSPSSRLEA
sp\|G1PZI4#1	---------RDLRAIVTETREEIARR--R----REAT	V	LYAACHVQPSASL-DTTEPQVTGLVLFRQLAPGGRLDA
sp\|G3ID79#1	IRPDLAEKINETHAKVLEIWMELRRL--REV---DAT	E	MYAICQVQPSASL-ATDQPRVTGLVLFKQLSPSSRLEA
sp\|Q08420#1	-RLDLVEKIGDTHSKDLEIWMELGKQ--REA---DAR	E	MHAVCRVQPSAML-PPDQPQITGLVLFRQLGPSSRLEA
sp\|Q64466#1	---DLVEKIGDTHAKVLEIWMELGRR--REV---DAA	E	MHAICRVQPSATL-PPDQPQITGLVLFRQLGPGSRLEA
sp\|O09164#1	---DLVEKIGDTHAKVLEIWMELGRR--REV---DAA	E	MHAICRVQPSATL-PPDQPQITGLVLFRQLGPGSRLEA
sp\|O88592#1	---DLVEKIGDTHAKVLEIWMELGRR--REV---DAA	E	MHAICRVQPSATL-PPDQPQITGLVLFRQLGPGSRLEA
sp\|Q3UM12#1	---DLVEKIGDTHAKVLEIWMELGRR--REV---DAA	E	MHAICRVQPSATL-PPDQPQITGLVLFRQLGPGSRLEA
sp\|F6UAR4#1	----NGEQMNDIQKKVSDLWHRLIYL-KPVTSGSDDH	I	VYATCQVQPSSTL-EANKPQVTGQVLFKQLYPDGKMEV
sp\|UPI000223E5E1#1	----------------------------------DED	P	VYAACEVKPSSIL-EADQPRVTGRVLFRQQYPDGRLEA
sp\|G3W9F8#1	-----AEQITDIQKKVGDLWNKLIYL-KPVTSGHDEH	T	VYATCQVKPSSTL-EAGKPQVTGQVLFKQLYPNGKMDV
sp\|A9JTW5#1	------ELLTDTNKKVNELWINLLNM----KPTDNDG	I	AYATCSLSPSSKL-EPSEVKVTGLVLFKQVFPSGTLEA
sp\|G1K8G8#1	VQPTAVSPLQDIQKKVNELWSSLLYPHLYEEVLASNG	T	AYAVCTVKPSTKL-DAGMPQVTGQVLFRQTYPYGKLES
sp\|UPI0000E8048A#1	GADPSSALLHDIQRKVNDLWQSLLYP--VMADNETDG	L	TYATCEVKPSSKI-DADKPQVTGQVLFRQHYSQGKLEA
sp\|G5BE34#1	PSPELMEQIHDMHTKVTDIWQELTQW--REAAGGPDV	G	LHAVCHMQPSATL-DAEQPRVSGLVLFRQPGPGARLEA
sp\|UPI0001C9C255#1	GADPSCASLHDVQRKVNDLWQSLLYP--VMADNETDG	L	TYATCEMKPSSKI-GADKPQVTGQVLFRQHYSQGRLEA
sp\|G1NIN0#1	GADPSCASLHDVQRKVNDLWQSLLYP--VMADNETDG	L	TYATCEMKPSSKI-GADKPQVTGQVLFRQHYSQGRLEA
sp\|UPI000194C39C#1	------ESLNEIQKQVNDLWQNLLYP--VTNGNDTDG	M	IYATCEMKPSSKI-DADKPQVTGQVLFRQSYSYGRLEA
sp\|F1NHI4#1	-------------------------------------	-	-YATCEVKPSSKI-DADKPQVTGQVLFRQHYSQGKLEA
sp\|E9QIM2#1	-------------------------------------	S	LQAVCRMQPNTRL-EPGMPRVYGHILFRQSGPKEKLSV
sp\|B8JKE9#1	-------------------------------------	S	LQAVCRMQPNTRL-APGMPRVYGHILFRQSGPKEKLSV
sp\|G1LPB6#1	PGSSTEAQIRDMHAKVTAIWQELTQR-----------	-	---QAAADXSATL-DTAQPRVSGLVLFRQLAPGARLEA
sp\|UPI00017B4836#1	----------------------------------NNG	S	LYAACNMRPSALL-PEDLPKVHGHVLFKQDHPQGGLSA
sp\|UPI00022B401A#1	------------------------------EVLQNNG	T	LYAVCKVRPSTSL-PEDLPKVYGHVLFKQDHPQEKVKV
sp\|B5X798#1	-------------------------------------	T	VYAACKMRPSTKL-GEGLPNVYGQVLFKQEYPEGSLKV
sp\|F1R0Y7#1	-----------------------------------NN	T	IYATCEVSPIPNL-PAGQPEIFGQVLFRQVFPNGTAEV
sp\|A5PLA4#1	-----------------------------------NN	T	IYATCEVSPIPNL-PAGQPKIFGQVLFRQVFPNGTAEV
sp\|G3Q125#1	-----------------------------------NG	T	LYAACKMRPSTSL-ADGLPKVYGQVLLKQDYPLGKLNA
sp\|Q4S6J6#1	-------------------------------------	-	----CNMRPSALL-PEDLPKVHGHVLFKQDHPQGGLSA
sp\|D2I2A5#1	PGSSTEAQIRDMH------------------------	-	----------------AKPRVSGLVLFRQLAPGARLEA
sp\|Q5GR13#1	-----------------------------------DE	Y	MYARCEMGMNPVM-ANTPHNIQGTIFLRQK-IYQPLEV
sp\|Q8I806#1	-------------------------------------	-	--AMCYMKPNPVLPDTIDTKVTGTVMLSQKSPSAKIKI
sp\|UPI0001CBB87A#1	-----------------------------------VY	A	GCSLRANPVQNID-PDINRPIEGYIEARQLISGGVVDI
sp\|UPI0001CBB879#1	-----------------------------------IH	A	GCYLRPNPSLNSN-DEIYRPIEGSIHVKQLTSGGDVEI
sp\|UPI0001CBA0DE#1	-------------------------------------	-	--------------------------------------
sp\|G3MQI9#1	-------------------------------------	-	------------------GPVFMQLFFVQESIEHSVVI
sp\|UPI0001CBB87A#2	-----------------------------------IH	A	GCYLRPNPSLNSN-DEIYRPIEGSIHVKQLSTGGEVEI
sp\|UPI0001CBB87B#1	------------------------EEIIQPAAEEYIY	A	GCYMTPDPALEKD-AALYKPIEGTISVKQRSTGGNIDI
sp\|B7QH32#1	-------------------------------------	-	--------------VLNAGEIRGIVQFAQL-NASHVRV
sp\|E7CQT9#1	-------------------------------------	G	LHSTCELAPDA---EGGPDGVSGTLDFLQKTERDPVHV
sp\|B7PEF3#1	-------------------------------------	-	-DEDVTDAICKLT-QPAGGNLTGVLSFQQNDPEDLVTI
sp\|G4XHW2#1	-------------------------------------	-	--------------------VTGTLTLEQLRPTSPVLI
sp\|E0VY69#1	-------------------------------------	-	--------------------LTGDVIFRQTNPEDPVEI
sp\|D6X0S3#1	-------------------------------------	-	-----------------------IVFFQRHPPNGPILV
sp\|Q90023#1	-------------------------------------	-	------TKPVSAI-AVLEGPVKGTVRFVE--ESSKVKI
sp\|C5KTS7#1	----------------------------------GSL	F	PIFPIRASANLVA-RESRSPARGIFYFEQV-GHARTKI
sp\|D2DSH2#1	-------------------------------------	-	------YAECVLK-ASSKSNVTGTLSLVQSRSFLPVLI
sp\|B7QEW8#1	-------------------------------------	-	-----------------------------------LNV
sp\|E9FXW0#1	-------------------------------------	-	--AVCEMKPNKAL-QRTKHNIVGKVAFTQT-TGGPLNV
sp\|G0MK39#1	-------------------------------------	-	-------------------ELIGTIDFDQ--SGSFLKL
sp\|G4M0N2#1	-------------------------------------	-	----------------VTPPYSGTVYFTK--HGSNLRV
sp\|B6HFF6#1	-------------------------------------	-	--------------------------------------
sp\|E3TD71#1	-------------------------------------	-	-----NVKNGIVL-MTANPNYSGQVFMRTNSDGMTSSL
sp\|F5GTG7#1	-------------------------------------	-	--------------------------------------
sp\|A7L9U0#1	-------------------------------------	-	--------------DGDPQKLIGIIDFVQ--YRSLVKL
sp\|Q53CP2#1	-------------------------------------	-	--------------DGDPQKLIGIIDFVQ--YRSLVKL
sp\|E2BYV3#1	-------------------------------------	-	--------------------------------------
sp\|F1LCL1#1	-------------------------------------	-	--------------------LLGIIDFTQ--FGGTLKI
sp\|E9J9R9#1	-------------------------------------	-	--------------------------------------
sp\|C3YVA5#1	-------------------------------------	-	--------------------------------------
sp\|Q9XYS0#1	-------------------------------------	-	--------------------------------------
sp\|G5ECR5#1	-------------------------------------	-	---------------------------------SFLKL
sp\|P34461#1	-------------------------------------	-	---------------------------------SFLKL
sp\|A7K8F0#1	-------------------------------------	-	-----NTKPIQAI-AVLPGDVSGTVRFVE--EGKRVRV
sp\|A7J6E5#1	-------------------------------------	-	--------------------VSGTVRFEE--EGSKVKI
sp\|F4WBA7#1	-------------------------------------	-	-------------------------------------V
sp\|A8XAB4#1	-------------------------------------	-	---------------------------------SFLKL
sp\|E3LSE9#1	-------------------------------------	-	---------------------------------SFLKL
sp\|A7ITH9#1	-------------------------------------	-	--------------------VSGTVRFEE--EGSKVKI
sp\|A7UL77#1	-------------------------------------	-	--------------------VAGTIVFHHMRGSTTIHI
sp\|Q45Q33#1	-------------------------------------	-	--------------------VAGTIVFHHMRGSTTIHI
sp\|C3YDS5#1	-------------------------------------	-	--------------------------------------
sp\|C5H405#1	-------------------------------------	-	--ARCEIMPNKEI-TDLAYRVRGHVKLSQKPGQDNISL
sp\|P51547#1	-------------------------------------	-	-------------------KTVGIIDLVQ--TGTLVKM
sp\|UPI0001925053#1	-------------------------------------	-	-------------------------------------I
sp\|A0S5T9#1	-------------------------------------	-	-------------------------------------I
sp\|E2B222#1	-------------------------------------	-	--------------------------------------
sp\|UPI0000220AB3#1	-------------------------------------	-	---------------------------------SFLKL
sp\|D9I7Q3#1	-------------------------------------	-	-------------------------------------I
sp\|C8XTB0#1	-------------------------------------	-	--------------------------------------
sp\|Q9NB64#1	-------------------------------------	-	--------------------------------------
sp\|E5EQ52#1	-------------------------------------	-	-----------------HPNIKGVVEFSEKGNKVVIKG
sp\|A7RX84#1	-------------------------------------	-	--------------------------------------
sp\|C1BSR9#1	---------------------------TANVIEPGVV	R	SSRNPRTKVTLFK-RGNTSEPIGNIYLME--MNGVVIL
sp\|UPI0001CBB879#2	---------------------------------GYIY	G	GCYIRPNPS-GIN-VALRKNIEGIIEIKQKSTGGEVEI
sp\|F2Y0Q6#1	-------------------------------------	-	----------------------GIVKFTE--ENNEVKI
sp\|D4QFJ5#1	-------------------------------------	A	LHAHCEVTPNTQT-PGLSYKIRGHIELTQEPHHDEVTL
sp\|D4QFJ4#1	-------------------------------------	A	LHAHCEVTPNTQT-PGLSYKIRGHIELTQEPHHDEVTL
sp\|D4QFJ6#1	-------------------------------------	A	LHAHCEVTPNTQT-PGLSYKIRGHIELTQEPHHDEVTL
sp\|C1BQG7#1	-------------------------------------	-	--------------------------------------
sp\|P16026#1	-------------------------------------	-	--------------------------------------
sp\|Q5DG63#1	-------------------------------------	-	--------------------------------------
sp\|C0CYN1#1	-------------------------------------	-	----------VTG-NSKAPQLSGLVKFYHT-PYGGVLV
sp\|C1C108#1	-------------------------------------	-	--------------------------------------
sp\|Q5BWZ1#1	-------------------------------------	-	--------------------------------------
sp\|E9GVW1#1	-------------------------------------	-	----------AVV-TISNGEINGKIVFEQASLKSPVKI
sp\|G0WPB5#1	-------------------------------------	-	--------------------------------------
sp\|E9GTP1#1	-------------------------------------	-	--------------------------------------
sp\|F6JYC7#1	-------------------------------------	-	--------------------------------------
sp\|G0Y2K4#1	-------------------------------------	-	--------------------------------------
sp\|UPI0000E80489#1	-------------------------------------	-	--------------------------------------

Shown are 75 amino acids surrounding the mutation position (marked with a black box). An interactive version of the complete alignment is also available.

3D Visualization