Human HnRNPA1 non synonymous SNP analysis in Amyotrophic Lateral Sclerosis

Position Natural Variant nsSNPAnalyzer PhD-SNP Polyphen-2 SIFT SNAP SNPs&GO Provean Aggregation Tendency (TANGO) Amyloid Propensity (WALTZ) Chaperone Binding Tendency (LIMBO) Structural Analisys Natural variant
73 Asn73Ser Neutral Neutral Neutral Neutral Neutral Neutral Neutral Not affect Not affect Not affect Structure N73S
314 Asp314Val Neutral Disease Disease Disease Disease Neutral Disease Not affect Increase Not affect Structure D314V
314 Asp314Asn Neutral Neutral Neutral Disease Disease Neutral Disease Not affect Increase Not affect Structure D314N
319 Asn319Ser Neutral Disease Neutral Disease Neutral Neutral Neutral Not affect Decrease Not affect Structure N319S